Similarly to wavelet transform, the MSBF is also defined as a weighted sum of nucleotides. PTMs are also important for allowing the recycling of proteins if they are no longer needed - a critical example of this is in the cell cycle where regulators for some the stages must be broken down to allow the next stage to proceed normally. The first is the introduction of a genomic-inspired multiscale bilateral filtering (MSBF) which exploits both weighting coefficients in the spatial domain and nucleotide similarity in the range. This has multiple advantages - for example, this saves cells energy and time (synthesizing new mRNAs and then proteins is energy intensive and slow compared with making PTMs). The exon-intron junction of 3 subunit gene of. Attenuation can add another 10 fold decrease in expression.īoth mechanisms thus work together to give a better level of control.Ģ) Post-translational modifications (PTMs) have the additional advantage of often being reversible - you don't need to make new proteins a cell can just fine tune their activity as needed. ino acid sequence from the exons showed 98 similarity with that of rat gene. coli trp operon the repressor is reported to decrease expression by about 70 fold. Good question, but too complex to answer completely here - I'll give you a few advantages, but I encourage you to read more about this subject on your own.ġ) Biological systems are quite error prone, so overlapping mechanisms often are used to achieve tighter control.įor example, in the E.
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